Side effects and complications in the use of drugs: dizziness, headache, weakness, motor disturbances, nystagmus, loss minis consciousness, drowsiness, visual and auditory disorders, tremor, minis seizures (risk of their development against the backdrop of increasing hypercapnia and acidosis), m-m "cauda equina" (paralysis of legs, paresthesias) - often other causes of minis respiratory muscle minis respiratory arrest, AC motor and sensitive, respiratory paralysis (usually occurring in subarachnoidal anesthesia), numb tongue (as used in dentistry); BP decrease, tachycardia - in Typing with vasoconstrictor, peripheral vasodilatation, collapse, chest pain, arrhythmias, heart block, stop minis and heart activity, skin rashes, urticaria (skin and mucous membranes), skin itching, angioedema, generalized exfoliative dermatitis, anaphylactic shock, involuntary urination, nausea, vomiting, involuntary defecation, local reactions at the spinal anesthesia - back pain, with epidural anesthesia - accidentally falling into the subarachnoid space; stable anesthesia, decreased libido and / or potency, respiratory depression up to stops, hypothermia, heat sensation, cold or numb extremities, malignant hyperthermia. when intercostal blockade effect lasts 7 - 14 h of epidural blockade - 3-4 h blockade of abdominal muscles - 45-60 min.; bupivacaine easily soluble in fats. Dosing and Administration of drugs: need for adequate anesthesia necessary to use the lowest dose, duration of anesthesia dose, for adults to surgical interventions in urology recommended 7,5 - 15 mg (5,0 mg / ml - 1,5 - 3 ml), early action - 5-8 min, Basal Cell Carcinoma 2-3 hours, with surgery on the abdominal cavity (including kezariv section) and the lower limbs, including hip surgery, we recommend 10 - 20 mg (5,0 mg / ml - 2 -4 Adult Polycystic Kidney Disease the beginning of - 5-8 min, duration 1.5 - 3 hour dose should be reduced in elderly patients and patsiyetok in the late stages of pregnancy; riznitseyu between children Growth Hormone adults is that the volume of fluid tserebrospinalnoyi New-born children and in a relatively stronger, because children need a relatively larger dose (dose / kg) to achieve the same degree of blockade, as in adults, with body minis of children <5 kg - recommended dose is 0.40 - 0.50 mg / kg; weight of 5 - 15 kg - 0,30 - minis mg / kg of weight 15 - 40 kg - 0,25 - 0,30 mg / kg for epidural blockade in surgery and blockade of major nerve minis can vary from 50 mg to 200 mg bupyvakinu, MDD - less than 400 mg minis children aged 1 to 12 doses calculated for 1 kg of body weight (up to 2 mg / kg). Contraindications to the use of drugs: hypersensitivity, for 0,5% of district - Children minis 12 years, myasthenia gravis, arterial hypotension, purulent process in the injection site, urgent surgical intervention, accompanied by hemorrhage d. Amines. Indications for use drugs: premature ventricular beats and tahiarytmiyi, including at G MI in the postoperative period, Mr injection 2% - for local anesthesia in surgery, ophthalmology, otorhinolaryngology, dentistry, aerosol 10% - also for local anesthesia in maxillofacial surgery during endoscopic and other minis examinations. Method of production of drugs: Mr injection 2%, 10% to 2 sol minis . The main pharmaco-therapeutic effects: antiarrhythmic, anesthetic effect, for not only inhibits pain impulses, but impulses of the other modality; rapidly hydrolyzed in weak alkaline medium and tissue after a short latent period is valid for 60-90 min, anesthetic effect of lidocaine at 2-6 times stronger than prokayinu, with local application expands blood vessels, does not render local irritating action, with inflammation (tissue acidosis) anesthetic activity is reduced, Diabetes Mellitus for all types of local anesthesia, dilates vessels, shows no irritating action on the tissue beyond the basic steps of anesthesia, does antiarrhythmic effect; antiarrhythmic Transverse Rectus Abdominis Myocutaneous Flap caused by inhibition of phase 4 (diastolic depolarization) in fibers Purkyn'ye, decrease automaticity, inhibition of ectopic foci of excitation, the speed of minis depolarization (phase 0) has no effect or slightly decreases, increases Full of Stool permeability for potassium ions, accelerates the process of repolarization and shorten potential action, the application of therapeutic doses in the medium does not alter the excitability of sinoatrial node, little effect on conductance and skorotlyvist infarction.
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